Q. What does it mean to pray "in the Spirit?"
A. To pray "in the Spirit" is to pray knowing God is present and active in my life.
God the Spirit is on site and constantly at work in every believer’s life. We need to pray, therefore, in dependence on Him and His work. It’s not some "spooky" trance, but it is supernatural. Wayne Grudem says, "To pray ‘in the Holy Spirit’ then, is to pray with the conscious awareness of God’s presence surrounding us and sanctifying both us and our prayers" (Systematic Theology, pg. 382).